6th Annual Gene Therapy Symposium for Heart, Lung, and Blood Diseases
Focus Topic: RNAi and Therapeutic Targeting
November 14-16, 2007 - Sonoma, California

Program

Wednesday, November 14, 2007 - Welcoming Reception

Thursday, November 15, 2007

Keynote Speaker

• Judy Lieberman, M.D. Ph.D. (Harvard University)
  “Delivering RNA Interference”

Session I  

• Paula M. Cannon, Ph.D. (Childrens Hospital Los Angeles)
  “Can We Reduce the Mutagenic Potential of Integrating Vectors?”

• Mark A. Kay, M.D., Ph.D. (Stanford University)
  “Defining the Rate-Limiting Factors for RNAi and microRNA Function in Mammals”

• Mark E. Davis, Ph.D. (California Institute of Technology)
  “Systemic Delivery of siRNA via Targeted Nanoparticles

Session II   

• Alfred S. Lewin, Ph.D. (University of Florida)
  “AAV-Mediated RNA Interference Leads to Improved Contractility and Calcium Handling in Cardiomyocytes”
  
  
• Ralph A. Tripp, Ph.D. (University of Georgia)
  “RNAi and Therapeutic Targeting of Respiratory Virus Infections”

• Bruce A. Sullenger, Ph.D. (Duke University)
  “Therapeutic Applications of Aptamers that Target Cell Surface Receptors”

“Practical Strategies”: RNAi Libraries

• William C. Hahn, M.D., Ph.D., (Dana-Farber Cancer Institute)

Friday, November 16, 2007

Workshop: “The Nuts and Bolts of RNAi for Therapeutic Applications”

• John J. Rossi, Ph.D.
  (Beckman Research Institute of the City of Hope)

Session III

• Michael T. McManus, Ph.D. (University of California, San Francisco)
  “Mammalian RNA Interference Pathways”

• K. Sue O'Shea, Ph.D. (University of Michigan)
  “Probing Gene Function in Development: RNAi in ES cells and Embryos”
  
  
• Ian MacLachlan, Ph.D. (Protiva Biotherapeutics, Inc.)
  "Preclinical Pharmacology of a SNALP Delivered siRNA-based Therapy for Hypercholesterolemia"

Session IV

• Tariq M. Rana, Ph.D. (University of Massachusetts)
  “Small RNAs: Regulators and Guardians of the Genome”
  
  
• Kathleen M. Sakamoto, M.D., Ph.D. (University of California, Los Angeles)
  “Downregulation of CREB in Normal and Neoplastic Hematopoietic Cells”
  
  
• Meri T. Firpo, Ph.D. (University of Minnesota)
  “Does OCT4 Regulate Self-Renewal in Adult and Embryonic Stem Cells?”